MovDisordV3, Main, Exploration, bibRecord, 004062

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Identifieur interne : 004062 ( Main/Exploration ); précédent : 004061; suivant : 004063

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Auteurs : Masataka Nishimura [Japon] ; Sadako Kuno [Japon] ; Ikuko Mizuta [Japon] ; Mitsuhiro Ohta [Japon] ; Hirofumi Maruyama [Japon] ; Ryuji Kaji [Japon] ; Hideshi Kawakami [Japon]

Source :

Movement Disorders [ 0885-3185 ] ; 2003-08.

RBID : ISTEX:03E3FE011DF143E4C2692E5BAF52E16C492C7779

Descripteurs français

Pascal (Inist)
- Allèle, Déterminisme génétique, Facteur risque, Gène, Génotype, Homme, Parkinson maladie, Polymorphisme, Protéine MCP1, Récepteur chimiokine CCR2, Sporadique.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Age of Onset, Aged, Aged, 80 and over, Allele, CCR2 chemokine receptor, CCR‐2, Chemokine CCL2 (genetics), Female, Gene, Genetic determinism, Genotype, Human, Humans, MCP‐1, Male, Middle Aged, Monocyte chemoattractant protein 1, Parkinson Disease (epidemiology), Parkinson Disease (genetics), Parkinson disease, Parkinson's disease, Polymorphism, Polymorphism, Genetic (genetics), Risk factor, Sporadic.
MESH :
- chemical , genetics : Chemokine CCL2.
- epidemiology : Parkinson Disease.
- genetics : Parkinson Disease, Polymorphism, Genetic.
- Adult, Age of Onset, Aged, Aged, 80 and over, Female, Genotype, Humans, Male, Middle Aged.

Abstract

We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society

Url:

https://api.istex.fr/document/03E3FE011DF143E4C2692E5BAF52E16C492C7779/fulltext/pdf

DOI: 10.1002/mds.10462

Affiliations:

Japon

Le document en format XML

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<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Allele</term>
<term>CCR2 chemokine receptor</term>
<term>CCR‐2</term>
<term>Chemokine CCL2 (genetics)</term>
<term>Female</term>
<term>Gene</term>
<term>Genetic determinism</term>
<term>Genotype</term>
<term>Human</term>
<term>Humans</term>
<term>MCP‐1</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Monocyte chemoattractant protein 1</term>
<term>Parkinson Disease (epidemiology)</term>
<term>Parkinson Disease (genetics)</term>
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<term>Risk factor</term>
<term>Sporadic</term>
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<term>Polymorphism, Genetic</term>
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<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<term>Déterminisme génétique</term>
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<term>Génotype</term>
<term>Homme</term>
<term>Parkinson maladie</term>
<term>Polymorphisme</term>
<term>Protéine MCP1</term>
<term>Récepteur chimiokine CCR2</term>
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<front><div type="abstract" xml:lang="en">We studied polymorphisms in the genes for monocyte chemoattractant protein 1 (MCP‐1) and CC chemokine receptor (CCR)‐2 in 171 Parkinson's disease (PD) patients and 340 controls. Although no associations were found in alleles or genotypes, MCP‐1 −2518A/G genotype affected the age‐at‐onset of PD patients. This effect was also detected in a second PD group, suggesting a possible involvement of MCP‐1 in PD. © 2003 Movement Disorder Society</div>
</front>
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Movement Disorders (revue)

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Influence of monocyte chemoattractant protein 1 gene polymorphism on age at onset of sporadic Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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